Complete Genes May Pass from Food to Human Blood
Identifieur interne : 000F06 ( Main/Exploration ); précédent : 000F05; suivant : 000F07Complete Genes May Pass from Food to Human Blood
Auteurs : Sándor Spisák [Hongrie, États-Unis] ; Norbert Solymosi [Hongrie] ; Péter Ittzés [Hongrie] ; András Bodor [Hongrie] ; Dániel Kondor [Hongrie] ; Gábor Vattay [Hongrie] ; Barbara K. Barták [Hongrie] ; Ferenc Sipos [Hongrie] ; Orsolya Galamb [Hongrie] ; Zsolt Tulassay [Hongrie] ; Zoltán Szállási [États-Unis] ; Simon Rasmussen [Danemark] ; Thomas Sicheritz-Ponten [Danemark] ; S Ren Brunak [Danemark] ; Béla Molnár [Hongrie] ; István Csabai [Hongrie, États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and then absorbed by a complex active process and distributed to various parts of the body through the circulation system. Here, based on the analysis of over 1000 human samples from four independent studies, we report evidence that meal-derived DNA fragments which are large enough to carry complete genes can avoid degradation and through an unknown mechanism enter the human circulation system. In one of the blood samples the relative concentration of plant DNA is higher than the human DNA. The plant DNA concentration shows a surprisingly precise log-normal distribution in the plasma samples while non-plasma (cord blood) control sample was found to be free of plant DNA.
Url:
DOI: 10.1371/journal.pone.0069805
PubMed: 23936105
PubMed Central: 3728338
Affiliations:
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centrale</region></placeName></affiliation></author><author><name sortKey="Galamb, Orsolya" sort="Galamb, Orsolya" uniqKey="Galamb O" first="Orsolya" last="Galamb">Orsolya Galamb</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>2nd Department of Internal Medicine, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Tulassay, Zsolt" sort="Tulassay, Zsolt" uniqKey="Tulassay Z" first="Zsolt" last="Tulassay">Zsolt Tulassay</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Molecular Medicine Research Group, Hungarian Academy of Sciences, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Molecular Medicine 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wicri:level="3"><nlm:aff id="aff3"><addr-line>Department of Physics of Complex Systems, Eötvös University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Physics of Complex Systems, Eötvös University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Department of Physics and Astronomy, The Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physics and Astronomy, The Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23936105</idno><idno type="pmc">3728338</idno><idno 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Research Group, Hungarian Academy of Sciences, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Molecular Medicine Research Group, Hungarian Academy of Sciences, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Solymosi, Norbert" sort="Solymosi, Norbert" uniqKey="Solymosi N" first="Norbert" last="Solymosi">Norbert Solymosi</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Department of Physics of Complex Systems, Eötvös University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Physics of Complex Systems, Eötvös University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Department of Animal Hygiene, Herd Health and Veterinary Ethology, Szent István University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Animal Hygiene, Herd Health and Veterinary Ethology, Szent István University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Ittzes, Peter" sort="Ittzes, Peter" uniqKey="Ittzes P" first="Péter" last="Ittzés">Péter Ittzés</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Department of Physics of Complex Systems, Eötvös University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Physics of Complex Systems, Eötvös University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Bodor, Andras" sort="Bodor, Andras" uniqKey="Bodor A" first="András" last="Bodor">András Bodor</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Department of Physics of Complex Systems, Eötvös University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Physics of Complex Systems, Eötvös University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Kondor, Daniel" sort="Kondor, Daniel" uniqKey="Kondor D" first="Dániel" last="Kondor">Dániel Kondor</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Department of Physics of Complex Systems, Eötvös University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Physics of Complex Systems, Eötvös University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Vattay, Gabor" sort="Vattay, Gabor" uniqKey="Vattay G" first="Gábor" last="Vattay">Gábor Vattay</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Department of Physics of Complex Systems, Eötvös University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Physics of Complex Systems, Eötvös University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Bartak, Barbara K" sort="Bartak, Barbara K" uniqKey="Bartak B" first="Barbara K." last="Barták">Barbara K. Barták</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>2nd Department of Internal Medicine, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Sipos, Ferenc" sort="Sipos, Ferenc" uniqKey="Sipos F" first="Ferenc" last="Sipos">Ferenc Sipos</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>2nd Department of Internal Medicine, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Galamb, Orsolya" sort="Galamb, Orsolya" uniqKey="Galamb O" first="Orsolya" last="Galamb">Orsolya Galamb</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>2nd Department of Internal Medicine, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Tulassay, Zsolt" sort="Tulassay, Zsolt" uniqKey="Tulassay Z" first="Zsolt" last="Tulassay">Zsolt Tulassay</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Molecular Medicine Research Group, Hungarian Academy of Sciences, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Molecular Medicine Research Group, Hungarian Academy of Sciences, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>2nd Department of Internal Medicine, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Szallasi, Zoltan" sort="Szallasi, Zoltan" uniqKey="Szallasi Z" first="Zoltán" last="Szállási">Zoltán Szállási</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Children's Hospital, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Rasmussen, Simon" sort="Rasmussen, Simon" uniqKey="Rasmussen S" first="Simon" last="Rasmussen">Simon Rasmussen</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby</wicri:regionArea><wicri:noRegion>Lyngby</wicri:noRegion></affiliation></author><author><name sortKey="Sicheritz Ponten, Thomas" sort="Sicheritz Ponten, Thomas" uniqKey="Sicheritz Ponten T" first="Thomas" last="Sicheritz-Ponten">Thomas Sicheritz-Ponten</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby</wicri:regionArea><wicri:noRegion>Lyngby</wicri:noRegion></affiliation></author><author><name sortKey="Brunak, S Ren" sort="Brunak, S Ren" uniqKey="Brunak S" first="S Ren" last="Brunak">S Ren Brunak</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark</addr-line></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby</wicri:regionArea><wicri:noRegion>Lyngby</wicri:noRegion></affiliation></author><author><name sortKey="Molnar, Bela" sort="Molnar, Bela" uniqKey="Molnar B" first="Béla" last="Molnár">Béla Molnár</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Molecular Medicine Research Group, Hungarian Academy of Sciences, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Molecular Medicine Research Group, Hungarian Academy of Sciences, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>2nd Department of Internal Medicine, Semmelweis University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Csabai, Istvan" sort="Csabai, Istvan" uniqKey="Csabai I" first="István" last="Csabai">István Csabai</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Department of Physics of Complex Systems, Eötvös University, Budapest, Hungary</addr-line></nlm:aff><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Physics of Complex Systems, Eötvös University, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Department of Physics and Astronomy, The Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Physics and Astronomy, The Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and then absorbed by a complex active process and distributed to various parts of the body through the circulation system. Here, based on the analysis of over 1000 human samples from four independent studies, we report evidence that meal-derived DNA fragments which are large enough to carry complete genes can avoid degradation and through an unknown mechanism enter the human circulation system. In one of the blood samples the relative concentration of plant DNA is higher than the human DNA. 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Barták</name><name sortKey="Bodor, Andras" sort="Bodor, Andras" uniqKey="Bodor A" first="András" last="Bodor">András Bodor</name><name sortKey="Csabai, Istvan" sort="Csabai, Istvan" uniqKey="Csabai I" first="István" last="Csabai">István Csabai</name><name sortKey="Galamb, Orsolya" sort="Galamb, Orsolya" uniqKey="Galamb O" first="Orsolya" last="Galamb">Orsolya Galamb</name><name sortKey="Ittzes, Peter" sort="Ittzes, Peter" uniqKey="Ittzes P" first="Péter" last="Ittzés">Péter Ittzés</name><name sortKey="Kondor, Daniel" sort="Kondor, Daniel" uniqKey="Kondor D" first="Dániel" last="Kondor">Dániel Kondor</name><name sortKey="Molnar, Bela" sort="Molnar, Bela" uniqKey="Molnar B" first="Béla" last="Molnár">Béla Molnár</name><name sortKey="Molnar, Bela" sort="Molnar, Bela" uniqKey="Molnar B" first="Béla" last="Molnár">Béla Molnár</name><name sortKey="Sipos, Ferenc" sort="Sipos, Ferenc" uniqKey="Sipos F" first="Ferenc" last="Sipos">Ferenc Sipos</name><name sortKey="Solymosi, Norbert" sort="Solymosi, Norbert" uniqKey="Solymosi N" first="Norbert" last="Solymosi">Norbert Solymosi</name><name sortKey="Solymosi, Norbert" sort="Solymosi, Norbert" uniqKey="Solymosi N" first="Norbert" last="Solymosi">Norbert Solymosi</name><name sortKey="Tulassay, Zsolt" sort="Tulassay, Zsolt" uniqKey="Tulassay Z" first="Zsolt" last="Tulassay">Zsolt Tulassay</name><name sortKey="Tulassay, Zsolt" sort="Tulassay, Zsolt" uniqKey="Tulassay Z" first="Zsolt" last="Tulassay">Zsolt Tulassay</name><name sortKey="Vattay, Gabor" sort="Vattay, Gabor" uniqKey="Vattay G" first="Gábor" last="Vattay">Gábor Vattay</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Spisak, Sandor" sort="Spisak, Sandor" uniqKey="Spisak S" first="Sándor" last="Spisák">Sándor Spisák</name></region><name sortKey="Csabai, Istvan" sort="Csabai, Istvan" uniqKey="Csabai I" first="István" last="Csabai">István Csabai</name><name sortKey="Szallasi, Zoltan" sort="Szallasi, Zoltan" uniqKey="Szallasi Z" first="Zoltán" last="Szállási">Zoltán Szállási</name></country><country name="Danemark"><noRegion><name sortKey="Rasmussen, Simon" sort="Rasmussen, Simon" uniqKey="Rasmussen S" first="Simon" last="Rasmussen">Simon Rasmussen</name></noRegion><name sortKey="Brunak, S Ren" sort="Brunak, S Ren" uniqKey="Brunak S" first="S Ren" last="Brunak">S Ren Brunak</name><name sortKey="Sicheritz Ponten, Thomas" sort="Sicheritz Ponten, Thomas" uniqKey="Sicheritz Ponten T" first="Thomas" last="Sicheritz-Ponten">Thomas Sicheritz-Ponten</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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